Post-doctoral position

Inserm is the only French public organization entirely dedicated to biological, medical, and health research for populations. It has research laboratories throughout the country, grouped into 12 Regional Delegations. Our institute brings together 15,000 researchers, engineers, technicians, and administrative staff with a common goal: to improve everyone’s health through advances in knowledge about living organisms and diseases, innovation in treatments, and public health research.

Joining Inserm means becoming part of an institute committed to gender equality and professional parity, diversity, and support for employees with disabilities, from recruitment and throughout their careers. To promote well-being at work, Inserm actively pursues policies on working conditions, based in particular on a fair balance between personal and professional life.

Inserm was awarded the European HR Excellence in Research label in 2016 and is committed to evolving its recruitment and evaluation practices for researchers.

The Institute of Metabolic and Cardiovascular Diseases (I2MC) a leading biomedical research center dedicated to understanding metabolic, cardiovascular, and inflammatory diseases. Located in the heart of the scientific and biomedical campus, it brings together over 400 scientists, clinicians, and students from around the world. I2MC's cutting-edge facilities support research from molecular mechanisms to translational medicine, fostering collaboration across disciplines. Its close links with CNRS labs, and the Science University (University Toulouse III - paul Sabatier) make it a cornerstone of Toulouse's scientific ecosystem. At I2MC, researchers enjoy a stimulating international environment with strong connections to hospitals and biotech startups. Frequent scientific seminars, workshops and networking events promote collaboration and career development. English is widely used in research settings, ensuring smooth integration for international scientists.

Director: Dominique LANGIN
Address: 1 avenue Jean Poulhès – BP 84225 – 31432 Toulouse Cedex 4
Regional Delegation: Occitanie Pyrénées

We are seeking a highly motivated Postdoctoral Fellow to join our team investigating the cellular and molecular mechanisms underlying defective epithelial regeneration in inflammatory Bowel Disease (IBD). The project focuses on the characterization of intestinal tissues from IBD patients, using cutting-edge technologies including human intestinal and colorectal organoid cultures, gut-on-chip, genome editing and 3D imaging.

The intestinal epithelium undergoes continuous  regeneration, which is impaired in chronic inflammatory conditions such as Crohn's disease and ulcerative colitis. The successful candidate will investigate cellular events and signaling pathways responsible for defective regeneration by integrating ex vivo patient-derived organoid models, high-resolution imaging, and functional genetic perturbation approaches. This work aims to uncover therapeutic targets for restoring eputhelial integrity and promoting mucosal healing.

• Experience working with patient-derived samples
• Familiarity with epithelial biology or gastrointestinal research
• Background in inflammatory diseases or regenerative medicine