Research program
on organs- and organoids-on-chip
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The exploratory research program Organs and organoids on chips (PEPR MED-OOC) aims to deploy a new generation of biological models in France through the development of organs and organoids on chips (O&OoC). The State has entrusted its management to the CEA, the CNRS and Inserm, and the scientific direction to Xavier Gidrol (CEA), Anne-Marie Gué (CNRS), and Jean Rosenbaum (Inserm). MED-OOC is funded by France 2030 over 6 years and has a budget of €48.4 million operated by the National Research Agency (ANR).
Technology for microenvironment engineering and imaging for organs-on-a-chip (EnVie)
Modular and standardized reconstruction of organs on a chip, integrating microenvironment engineering and 3D imaging to reproduce their architecture and main functions.
Type 1 Diabetes on chip (MAGIC)
Development of vascularized pancreatic islets on a chip to monitor immune response and graft survival in patients with type 1 diabetes after transplantation.
Multi-organ coupling on a chip for metabolic syndrome monitoring (MSY-OOC)
Development of a new generation of human liver-on-a-chip to model liver dysfunctions in metabolic syndrome and interactions between involved organs.
Tumor-on-a-chip to improve patient care (TME On Chip)
Patient-derived tumor-on-a-chip modeling to predict efficacy and identify optimal personalized treatment by faithfully recapitulating patient pathology.
Advanced gut on a chip to decipher T γδ cells-mediated immune response to a viral or fungal infection (AUGMENT)
AUGMENT The AUGMENT project aims to design and validate a next-generation gut-on-chip (GoC) platform that…
Testis organ-on-chip: an asset to study spermatogonial stem cell fate and develop biotherapies of infertility (FERTILOoC)
FERTILOoC One in six couples worldwide experience infertility issues, and male infertility is responsible for…
Development of a neurocompetent multi segment intestinal OoC based on hiPSC for studying intestinal infectious diseases (HITOC)
HITOC HITOC addresses a major limitation in current in vitro models of the human intestine:…
A modular multi-organ-on-chip for personalized medicine in chronic obstructive pulmonary disease – COPD (MICROCOSM)
MICROCOSM Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, characterized…
Microassays of immune cells functional analysis for routine personalized clinical oncology (MOHICAN)
MOHICAN The MOHICAN project aims to develop new medical devices enabling functional testing of patient…
The Skeletal Muscle complexity Recapitulated on-a-Chip to model Neuromuscular Diseases and predict treatment efficacy (MUSCLOR-oC)
MUSCLOR-oC Skeletal muscle is the most abundant tissue in the human body and plays essential…
Integrated Human Neuromuscular-on-Chip and Virtual Replica Platform for diagnosis, disease modeling and drug evaluation (NeMOCHIP)
NeMOCHIP NeMOCHIP aims to fully harness human pluripotent stem cell (hPSC)-based strategies, advanced bioengineering, and…
Optic Nerve-on-Chip: A 3D iPSC-Based Platform for Vision Repair and Drug Discovery (On-CHIP)
ON-CHIP Glaucoma, particularly primary open-angle glaucoma (POAG), is a multifactorial neurodegenerative disease resulting from complex…
SOFT Tumor On Chip mimicking Endometrial tumor microenvironment to predict therapeutic efficacy (SOFTER)
SOFTER SOFTER aims to develop a next-generation Tumor-on-Chip (ToC) model that recapitulates the tumor microenvironment…
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PEPR MED-OOC’s 2nd Annual Scientific Meeting 2026
Monday 1st and Tuesday 2nd of June, 2026: two days of discussions and scientific encounters around organs and organoids on chip.
11 February 2026
Vers une médecine personnalisée : le programme MED-OOC fait avancer la recherche sur les organes et organoïdes sur puces – La gazette du laboratoire (février 2025)
“MED‑OOC a pour conviction de faire entrer les organes et organoïdes sur puces dans le parcours de soins et compte bien rendre cette conviction réaliste sur le terrain grâce à ses avancées en termes de R&D.”
Dans son édition de février 2025, La Gazette du Laboratoire met en lumière le programme Organes et organoïdes sur puces : ses enjeux, ses actions clés, ses points forts et sa gouvernance. Un article à lire pour mieux comprendre les enjeux du programme.
14 November 2025
Les organes sur puce : un bond décisif pour la médecine – Sciences & Vie (juillet 2024)
Mieux personnaliser les traitements, diminuer le taux d’échec des essais cliniques et limiter les tests sur animaux, telles sont les ambitions de cette technologie ultra-prometteuse. Explications du magazine Sciences & Vie – Juillet 2024
14 November 2025
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